Product Detail
Product NameCaspase-9 Rabbit mAb
Clone No.SC65-05
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAPAF-3 antibody
APAF3 antibody
Apoptosis related cysteine peptidase antibody
Apoptotic protease Mch-6 antibody
Apoptotic protease-activating factor 3 antibody
CASP-9 antibody
CASP9 antibody
CASP9_HUMAN antibody
Caspase 9 apoptosis related cysteine peptidase antibody
Caspase 9 Dominant Negative antibody
Caspase 9c antibody
Caspase-9 antibody
Caspase-9 subunit p10 antibody
ICE LAP6 antibody
ICE like apoptotic protease 6 antibody
ICE-LAP6 antibody
ICE-like apoptotic protease 6 antibody
MCH6 antibody
PPP1R56 antibody
protein phosphatase 1, regulatory subunit 56 antibody
RNCASP9 antibody
Accession NoSwiss-Prot#:P55211
Uniprot
P55211
Gene ID
842;
Calculated MW46/39/37/35 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of Caspase-9 on different lysates using anti-Caspase-9 antibody at 1/1,000 dilution. Positive control:
Lane 1: Jurkat
Lane 2: Hela
Lane 3: C2C12
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
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