Product Detail
Product NameFNTB Rabbit mAb
Clone No.SC06-44
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCAAX farnesyltransferase subunit beta antibody EC 2.5.1.58 antibody EC=2.5.1.58 antibody Farnesyltransferase antibody farnesyltransferase CAAX box beta1 antibody farnesyltransferase, CAAX box, beta antibody FNTB antibody FNTB_HUMAN antibody FPTB antibody FTase beta antibody FTase-beta antibody MGC105303 antibody Protein farnesyltransferase subunit beta antibody RAS proteins prenyltransferase beta antibody Ras proteins prenyltransferase subunit beta antibody
Accession NoSwiss-Prot#:P49356
Uniprot
P49356
Gene ID
100529261;2342;
Calculated MW43 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
ICC: 1:50-1:200
Western blot analysis of FNTB on K562 cells lysates using anti-FNTB antibody at 1/1,000 dilution.
ICC staining FNTB in JAR cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The β subunit, which is known as FTβ, CAAX farnesyltransferase subunit β, or Ras proteins prenyltransferase subunit β, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.
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