Product Detail
Product NameMyosin Light Chain 2 Rabbit mAb
Clone No.SN67-09
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP
Species ReactivityHu, Ms, Rt, zebrafish
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCardiac myosin light chain-2 antibody
Cardiac ventricular myosin light chain 2 antibody
CMH10 antibody
MLC 2v antibody
MLC-2 antibody
MLC-2v antibody
MLC2 antibody
MLRV_HUMAN antibody
MYL 2 antibody
MYL2 antibody
Myosin light chain 2 regulatory cardiac slow antibody
Myosin light polypeptide 2 regulatory cardiac slow antibody
Myosin regulatory light chain 2 antibody
Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody
Regulatory light chain of myosin antibody
RLC of myosin antibody
Slow cardiac myosin regulatory light chain 2 antibody
ventricular/cardiac muscle isoform antibody
Accession NoSwiss-Prot#:P10916
Uniprot
P10916
Gene ID
4633;
Calculated MW19 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200
Western blot analysis of Myosin Light Chain 2 on different lysates using anti-Myosin Light Chain 2 antibody at 1/1,000 dilution. Positive control:
Lane 1: Mouse liver
Lane 2: Mouse brain
Western blot analysis of Myosin Light Chain 2 on hybrid fish (crucian-carp) skin tissue lysate using anti-Myosin Light Chain 2 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Myosin Light Chain 2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Myosin Light Chain 2 antibody. Counter stained with hematoxylin.
Encoded by the MYL2 gene, myosin regulatory light chain 2, ventricular/cardiac muscle isoform, also designated MLC-2 or MLC2v, is part of a hexameric complex of two heavy chains and four light chains predominantly expressed in adult cardiac ventricle muscle. Myosin regulatory light chain 2 binds calcium and has been shown to be a useful molecular marker for cardiac chamber specification. The co-expression of myosin regulatory light chain 7 (MYL7) and myosin regulatory light chain 2 in the outflow tract and atrioventricular canal, together with the single expression in the atrial (MYL7) and ventricular (MYL2) myocardium, permits the delineation of their boundaries. At the amino acid level there is 96% homology between the human and mouse myosin regulatory light chain sequences. Mutations in MYL2 are correlated with mid-left ventricular chamber type hypertrophic cardiomyopathy (MVC2) as well as familial hypertrophic cardiomyopathy type 10 (CMH10).
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