Product Detail
Product NameAngiopoietin 1 Rabbit mAb
Clone No.SN67-02
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAGP 1 antibody AGP1 antibody AGPT antibody ANG 1 antibody ANG antibody ANG-1 antibody ANG1 antibody Angiopoietin-1 antibody Angiopoietin1 antibody ANGP1_HUMAN antibody ANGPT 1 antibody Angpt1 antibody KIAA0003 antibody OTTHUMP00000227592 antibody OTTHUMP00000227599 antibody OTTHUMP00000227600 antibody
Accession NoSwiss-Prot#:Q15389
Uniprot
Q15389
Gene ID
284;
Calculated MW57 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of Angiopoietin 1 on K562 cells lysates using anti-Angiopoietin 1 antibody at 1/1,000 dilution.
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling.
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