Product Detail
Product NameGPCR RDC1 Rabbit mAb
Clone No.SN65-09
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesACKR3 antibody atypical chemokine receptor 3 antibody C X C chemokine receptor type 7 antibody C-X-C chemokine receptor type 7 antibody Chemokine (C-X-C motif) receptor 7 antibody Chemokine C X C motif receptor 7 antibody Chemokine orphan receptor 1 antibody CMKOR1 antibody CXC R7 antibody CXC-R7 antibody CXCR 7 antibody CXCR-7 antibody CXCR7 antibody CXCR7_HUMAN antibody G protein coupled receptor 159 antibody G protein coupled receptor antibody G protein coupled receptor RDC1 homolog antibody G-protein coupled receptor 159 antibody G-protein coupled receptor RDC1 homolog antibody GPR159 antibody GPRN1 antibody RDC 1 antibody RDC-1 antibody RDC1 antibody
Accession NoSwiss-Prot#:P25106
Uniprot
P25106
Gene ID
57007;
Calculated MW41 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
FC: 1:10-1:100
Western blot analysis of GPCR RDC1 on PC-3M cells lysates using anti-GPCR RDC1 antibody at 1/1,000 dilution.
Flow cytometric analysis of Jurkat cells with GPCR RDC1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Members of the C-X-C or α chemokine family are characterized by a pair of cysteine residues separated by a single amino acid and primarily function as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins and include proteins such as IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). C-X-C chemokine receptor type 7 (CXCR-7), also known as RDC-1, is a 362 amino acid receptor for SDF-1. Initially identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor. CXCR-7, with CSCR-4, also acts as a coreceptor for human immunodeficiency viruses (HIV). Highly expressed in monocytes, B-cells and basophils, and highly active in various biological processes, including cell growth, cell adhesion and tumor growth, CXCR-7 may play a role in tumorigenesis.
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