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Location： Home > Recombinant Rabbit Monoclonal Antibodies > P Glycoprotein Rabbit mAb

P Glycoprotein Rabbit mAb#49042

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Product Detail

Product NameP Glycoprotein Rabbit mAb

Clone No.SN06-42

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesABC20 antibody
ABCB1 antibody
ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
ATP-binding cassette sub-family B member 1 antibody
CD243 antibody
CLCS antibody
Colchicin sensitivity antibody
Doxorubicin resistance antibody
GP170 antibody
MDR1 antibody
MDR1_HUMAN antibody
Multidrug resistance 1 antibody
Multidrug resistance protein 1 antibody
P glycoprotein 1 antibody
P gp antibody
P-glycoprotein 1 antibody
PGY1 antibody

Accession NoSwiss-Prot#:P08183

Uniprot P08183

Gene ID 5243;

Calculated MW180 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:1,000
IHC: 1:50-1:200
 

Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.

Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.

If you have published an article using product 49042, please notify us so that we can cite your literature.

et al,CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K鈥慉kt鈥憁TOR pathway inhibition. In Int J Oncol on 2021 Jul by Yu-Xin Liao, Ji-Yang Lv,et al..PMID:34080667 , (2021),
PMID: 34080667

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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