Product Detail
Product NameBTK Rabbit mAb
Clone No.SN69-07
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAgammaglobulinaemia tyrosine kinase antibody AGMX 1 antibody AGMX1 antibody AT antibody ATK antibody B cell progenitor kinase antibody B-cell progenitor kinase antibody BPK antibody Bruton agammaglobulinemia tyrosine kinase antibody Bruton tyrosine kinase antibody Brutons Tyrosine Kinase antibody Btk antibody BTK_HUMAN antibody dominant-negative kinase-deficient Brutons tyrosine kinase antibody IMD 1 antibody IMD1 antibody MGC126261 antibody MGC126262 antibody OTTHUMP00000063593 antibody PSCTK 1 antibody PSCTK1 antibody truncated Bruton agammaglobulinemia tyrosine kinase antibody Tyrosine protein kinase BTK antibody Tyrosine-protein kinase BTK antibody tyrosine-protein kinase BTK isoform (lacking exon 14 antibody XLA antibody
Accession NoSwiss-Prot#:Q06187
Uniprot
Q06187
Gene ID
695;
Calculated MW76 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of BTK on Raji cells lysates using anti-BTK antibody at 1/1,000 dilution.
The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.
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