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NEDD4-2 Rabbit mAb#49055

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Product Detail

Product NameNEDD4-2 Rabbit mAb

Clone No.SN73-03

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IP

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesE3 ubiquitin protein ligase NEDD4 like protein antibody
E3 ubiquitin-protein ligase NEDD4-like antibody
KIAA0439 antibody
NED4L_HUMAN antibody
NEDD4 2 antibody
NEDD4 2c antibody
Nedd4-2 antibody
NEDD4-2a antibody
NEDD4.2 antibody
NEDD4b antibody
NEDD4L antibody
NEDD4La antibody
NEDD4Lb antibody
NEDD4Lc antibody
NEDD4Ld antibody
NEDD4Le antibody
NEDD4Lf antibody
NEDD4Lg antibody
NEDD4Lh antibody
NEDL3 antibody
Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody
Neural precursor cell expressed, developmentally down regulated 4 like antibody
RSP5 antibody
Ubiquitin protein ligase Rsp5 antibody

Accession NoSwiss-Prot#:Q96PU5

Uniprot Q96PU5

Gene ID 23327;

Calculated MW112 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:1,000-5,000

 

Western blot analysis of NEDD4-2 on Jurkat cells lysates using anti-NEDD4-2 antibody at 1/1,000 dilution.

NEDD4-L (neural precursor cell expressed, developmentally down-regulated 4-like), also known as RSP5, NEDD4-2 or NEDL3, is a 975 amino acid protein that localizes to the cytoplasm and contains four WW domains, one HECT domain and one C2 domain. Expressed ubiquitously with highest expression in pancreas, prostate and kidney, NEDD4-L functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Through its ability to ubiquitinate and induce the proteasome-dependent degradation of proteins such as Smad2 and TGFβ RII, NEDD4-L is thought to inhibit the TGFβ signaling pathway, thereby regulating the signaling pathways that control cell growth and differentiation. NEDD4-L is expressed as eight isoforms due to alternative splicing events.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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