Product Detail
Product NameCytokeratin 1 Rabbit mAb
Clone No.SN72-08
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names67 kDa cytokeratin antibody CK-1 antibody CK1 antibody Cytokeratin-1 antibody Cytokeratin1 antibody EHK antibody EHK1 antibody Epidermolytic hyperkeratosis 1 antibody EPPK antibody Hair alpha protein antibody K1 antibody K2C1_HUMAN antibody Keratin antibody Keratin type II cytoskeletal 1 antibody Keratin-1 antibody Keratin1 antibody KRT 1 antibody Krt1 antibody KRT1A antibody NEPPK antibody type II cytoskeletal 1 antibody Type II keratin Kb1 antibody Type-II keratin Kb1 antibody
Accession NoSwiss-Prot#:P04264
Uniprot
P04264
Gene ID
3848;
Calculated MW72 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:100-1:500
Western blot analysis of Cytokeratin 1 on different lysates using anti-Cytokeratin 1 antibody at 1/1,000 dilution. Positive control: Lane 1: 293T Lane 2: Hela
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-Cytokeratin 1 antibody. Counter stained with hematoxylin.
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.
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