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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Integrin alpha 2 Rabbit mAb

Integrin alpha 2 Rabbit mAb#49071

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Product Detail

Product NameIntegrin alpha 2 Rabbit mAb

Clone No.SN0752

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesBR antibody
CD 49b antibody
CD49 antigen like family member B antibody
CD49 antigen-like family member B antibody
CD49b antibody
CD49b antigen antibody
Collagen receptor antibody
DX5 antibody
Glycoprotein Ia deficiency included antibody
GP Ia antibody
GP Ia deficiency, included antibody
GPIa antibody
HPA 5 included antibody
HPA5 included antibody
Human platelet alloantigen system 5 antibody
Integrin alpha 2 antibody
Integrin alpha-2 antibody
Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor) antibody
ITA2_HUMAN antibody
ITGA2 antibody
Platelet alloantigen Br(a), included antibody
Platelet antigen Br antibody
Platelet glycoprotein GPIa antibody
Platelet glycoprotein Ia antibody
Platelet glycoprotein Ia/IIa antibody
Platelet membrane glycoprotein Ia antibody
Platelet receptor for collagen, deficiency of, included antibody
Very late activation protein 2 receptor alpha 2 subunit antibody
VLA 2 alpha chain antibody
VLA 2 antibody
VLA 2 subunit alpha antibody
VLA-2 subunit alpha antibody
VLA2 antibody
VLA2 receptor alpha 2 subunit antibody
VLAA2 antibody

Accession NoSwiss-Prot#:P17301

Uniprot P17301

Gene ID 3673;

Calculated MW150 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:100-1:500

FC: 1:50-1:100

Western blot analysis of ITGA2 on A431 cells lysates using anti-ITGA2 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ITGA2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-ITGA2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ITGA2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-ITGA2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-ITGA2 antibody. Counter stained with hematoxylin.
ICC staining ITGA2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ITGA2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of A431 cells with ITGA2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The sixteen α and eight β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counter-receptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin α2 is responsible for adhesion of platelets and other cells to collagens. Modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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