Product Detail
Product NameCD38 Rabbit mAb
Clone No.SR4529
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAcute lymphoblastic leukemia cells antigen CD38 antibody ADP ribosyl cyclase 1 antibody ADP ribosyl cyclase antibody ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody ADP-ribosyl cyclase 1 antibody ADPRC 1 antibody ADPRC1 antibody cADPr hydrolase 1 antibody CD 38 antibody CD38 antibody CD38 antigen (p45) antibody CD38 antigen antibody CD38 molecule antibody Cd38-rs1 antibody CD38_HUMAN antibody CD38H antibody Cyclic ADP ribose hydrolase antibody Cyclic ADP ribose hydrolase 1 antibody Cyclic ADP-ribose hydrolase 1 antibody EC 3.2.2.5 antibody Ecto nicotinamide adenine dinucleotide glycohydrolase antibody I-19 antibody I19 (mouse) antibody Lymphocyte differentiation antigen CD38 antibody NAD(+) nucleosidase antibody NIM-R5 antigen antibody NIMR5 antigen (mouse) antibody OTTHUMP00000158633 antibody OTTHUMP00000217743 antibody p45 antibody T10 antibody
Accession NoSwiss-Prot#:P28907
Uniprot
P28907
Gene ID
952;
Calculated MW40/50 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
Western blot analysis of CD38 on different lysates using anti-CD38 antibody at 1/1,000 dilution. Positive control: Lane 1: THP-1 Lane 2: Raji
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD38 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD38 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CD38 antibody. Counter stained with hematoxylin.
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
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