Product Detail
Product NameDelta Opioid Receptor Rabbit mAb
Clone No.SN20-04
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesD-OR-1 antibody Delta type opioid receptor antibody Delta type opioid receptor DOR 1 antibody Delta type opioid receptor DOR1 antibody Delta-type opioid receptor antibody DOR 1 antibody DOR-1 antibody DOR1 antibody mDOR antibody Nbor antibody Opioid receptor delta 1 antibody OPRD 1 antibody OPRD antibody OPRD_HUMAN antibody Oprd1 antibody
Accession NoSwiss-Prot#:P41143
Uniprot
P41143
Gene ID
4985;
Calculated MW40 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
FC: 1:50-1:100
Western blot analysis of OPRD1 on different lysates using anti-OPRD1 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC Lane 2: Rat brain
Flow cytometric analysis of SH-SY-5Y cells with OPRD1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
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