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Location： Home > Recombinant Rabbit Monoclonal Antibodies > SMC1 Rabbit mAb

SMC1 Rabbit mAb#49114

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Product Detail

Product NameSMC1 Rabbit mAb

Clone No.SN20-27

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesCDLS2 antibody
DKFZp686L19178 antibody
DXhXs423e antibody
DXS423E antibody
KIAA0178 antibody
MGC138332 antibody
OTTHUMP00000061876 antibody
RP6 29D12.1 antibody
SB1.8 antibody
Segregation of mitotic chromosomes 1 antibody
Segregation of mitotic chromosomes like 1 antibody
SMC 1 antibody
SMC protein 1B antibody
SMC-1-beta antibody
SMC-1B antibody
SMC1 antibody
SMC1A antibody
SMC1alpha antibody
SMC1alpha protein antibody
SMC1B antibody
SMC1B_HUMAN antibody
SMC1BETA antibody
SMC1beta protein antibody
SMC1L1 antibody
SMC1L2 antibody
SMCB antibody
Structural maintenance of chromosome 1 like 1 protein antibody
Structural maintenance of chromosome 1 like 2 protein antibody
Structural maintenance of chromosomes 1A antibody
Structural maintenance of chromosomes 1B antibody
Structural maintenance of chromosomes protein 1B antibody

Accession NoSwiss-Prot#:Q14683

Uniprot Q14683

Gene ID 8243;

Calculated MW143 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:100-1:500

Western blot analysis of SMC1 on different lysates using anti-SMC1 antibody at 1/1,000 dilution. Positive control:
Lane 1: NIH/3T3
Lane 2: Hela
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-SMC1 antibody. Counter stained with hematoxylin.
ICC staining SMC1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SMC1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SMC1 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. SMC1α (structural maintenance of chromosomes protein 1A), also known as SMC1, SMCB, CDLS2, SB1.8, SMC1L1 or DXS423E, is a 1,233 amino acid nuclear protein that is involved in chromosome cohesion during the cell cycle. SMC1α interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role in DNA repair. SMC1α is a component of the cohesion complex, which is required for the cohesion of sister chromatids after DNA replication. Mutations in the gene encoding SMC1α may be the cause of Cornelia de Lange syndrome (CdLS), which is a clinically heterogeneous developmental disorder characterized by facial dysmorphia, upper limb malformations, growth and cognitive retardation.

If you have published an article using product 49114, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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