Product Detail
Product NameProstate Specific Antigen Rabbit mAb
Clone No.SD07-45
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Namesantigen, prostate-specific antibody APS antibody Gamma seminoprotein antibody Gamma-seminoprotein antibody hK3 antibody Kallikrein 3 antibody Kallikrein related peptidase 3 antibody Kallikrein-3 antibody KLK 3 antibody KLK2A1 antibody Klk3 antibody KLK3_HUMAN antibody P-30 antigen antibody P30 antigen antibody Prostate-specific antigen antibody Psa antibody Semenogelase antibody Seminin antibody
Accession NoSwiss-Prot#:P07288
Uniprot
P07288
Gene ID
354;
Calculated MW34 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-PSA antibody. Counter stained with hematoxylin.
ICC staining PSA in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Prostate specific antigen (PSA), also designated γ-seminoprotein, seminin, p30 antigen, semenogelase, and kallikrein 3 (KLK3), was first identified as a glycoprotein in human seminal plasma. PSA was determined by sequence similarity to be a member of the kallikrein subfamily of trypsin proteases. PSA is a serine protease that hydrolyzes the major human seminal protein, the seminal plasma mobility inhibitor precursor, or semenogelin I (SPMIP or SgI), which leads to semen liquification. PSA production and expression are highest in normal, benign hyperplastic and cancerous tissues of the prostate, although PSA has also been detected in accessory male sex glands and in breast cancer. PSA has been identified as an aid in the early detection of prostate cancer and is a commonly used tumor marker.
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