Product Detail
Product NameRUNX2 Rabbit mAb
Clone No.SD208-0
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsICC/IF, IHC, WB
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAcute myeloid leukemia 3 protein antibody
Alpha subunit 1 antibody
AML3 antibody
CBF alpha 1 antibody
CBF-alpha-1 antibody
CBFA1 antibody
CCD antibody
CCD1 antibody
Cleidocranial dysplasia 1 antibody
Core binding factor antibody
Core binding factor runt domain alpha subunit 1 antibody
Core binding factor subunit alpha 1 antibody
Core-binding factor subunit alpha-1 antibody
MGC120022 antibody
MGC120023 antibody
Oncogene AML 3 antibody
Oncogene AML-3 antibody
OSF 2 antibody
OSF-2 antibody
OSF2 antibody
Osteoblast specific transcription factor 2 antibody
Osteoblast-specific transcription factor 2 antibody
OTTHUMP00000016533 antibody
PEA2 alpha A antibody
PEA2-alpha A antibody
PEA2aA antibody
PEBP2 alpha A antibody
PEBP2-alpha A antibody
PEBP2A1 antibody
PEBP2A2 antibody
PEBP2aA antibody
PEBP2aA1 antibody
Polyomavirus enhancer binding protein 2 alpha A subunit antibody
Polyomavirus enhancer-binding protein 2 alpha A subunit antibody
Runt domain antibody
Runt related transcription factor 2 antibody
Runt-related transcription factor 2 antibody
RUNX2 antibody
RUNX2_HUMAN antibody
SL3 3 enhancer factor 1 alpha A subunit antibody
SL3-3 enhancer factor 1 alpha A subunit antibody
SL3/AKV core binding factor alpha A subunit antibody
SL3/AKV core-binding factor alpha A subunit antibody
Accession NoSwiss-Prot#:Q13950
Uniprot
Q13950
Gene ID
860;
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RUNX2 antibody. Counter stained with hematoxylin.
ICC staining RUNX2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-RUNX2 antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: MDA-MB-231 Lane 2: Saos-2 Lane 3: NIH-3T3 Lane 4: Rat womb
The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
If you have published an article using product 49158, please notify us so that we can cite your literature.
et al,Nanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariinInDrug Deliv On2023 DecbyXinxin Yu?1,?Ming Dong et al..PMID: 36714914
, (2023),
PMID:
36714914
et al,Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration.
, (2025),
PMID:
39951685
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