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AMPK beta 1 Rabbit mAb#49168

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Product Detail

Product NameAMPK beta 1 Rabbit mAb

Clone No.SD082-06

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names1300015D22Rik antibody
5''-AMP-activated protein kinase subunit beta-1 antibody
5'-AMP-activated protein kinase beta-1 subunit antibody
AAKB1_HUMAN antibody
AMP-activated protein kinase beta subunit antibody
AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1 antibody
AMP-activated, noncatalytic, beta-1 antibody
AMPK antibody
AMPK beta 1 chain antibody
AMPK subunit beta-1 antibody
AMPK-BETA-1 antibody
AMPKb antibody
AU021155 antibody
E430008F22 antibody
HAMPKb antibody
MGC17785 antibody
PRKAB1 antibody
Protein kinase AMP activated non catalytic subunit beta 1 antibody
protein kinase, AMP-activated, beta 1 non-catalytic subunit antibody
protein kinase, AMP-activated, noncatalytic, beta-1 antibody

Accession NoSwiss-Prot#:Q9Y478

Uniprot Q9Y478

Gene ID 5564;

Calculated MW38 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000



FC: 1:50-1:100
Western blot analysis of AMPK beta 1 on A431 cells lysates using anti-AMPK beta 1 antibody at 1/1,000 dilution.
Flow cytometric analysis of A431 cells with AMPK beta 1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex com-prising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming bio-synthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKα1 and AMPKα2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKβ1 encodes a 271 amino acid protein and human AMPKβ2 encodes a 272 amino acid protein. The human AMPKγ1 gene encodes a 331 amino acid protein. Human AMPKγ2 and AMPKγ3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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