Product Detail
Product NamePAX6 Rabbit mAb
Clone No.SD08-31
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAN 2 antibody AN antibody AN2 antibody Aniridia type II protein antibody D11S812E antibody FVH1 antibody KIAA0552 antibody Leucine zipper putative tumor suppressor 3 antibody LZTS3 antibody MGC17209 antibody MGDA antibody Oculorhombin antibody Paired box 6 antibody Paired box gene 6 (aniridia keratitis) antibody Paired Box Gene 6 antibody Paired box homeotic gene 6 antibody Paired box protein Pax-6 antibody Paired box protein Pax6 antibody PAX 6 antibody PAX6 antibody PAX6_HUMAN antibody ProSAP-interacting protein 1 antibody PROSAPIP1 antibody Sey antibody WAGR antibody
Accession NoSwiss-Prot#:P26367
Uniprot
P26367
Gene ID
5080;
Calculated MW48 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of PAX6 on Hela cells lysates using anti-PAX6 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded rat eyeball tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse eyeball tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
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