Product Detail
Product NameCytokeratin 2e Rabbit mAb
Clone No.JJ201-8
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCK 2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody
Accession NoSwiss-Prot#:P35908
Uniprot
P35908
Gene ID
3849;
Calculated MW65 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
Western blot analysis of Cytokeratin 2e on human skin lysates using anti-Cytokeratin 2e antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cytokeratin 2e antibody. Counter stained with hematoxylin.
The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder.
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