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KMT6/EZH2 Rabbit mAb#49267

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Product Detail

Product NameKMT6/EZH2 Rabbit mAb

Clone No.JJ089-9

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesEnhancer of zeste 2 antibody
enhancer of zeste 2 polycomb repressive complex 2 subunit antibody
Enhancer of zeste homolog 2 (Drosophila) antibody
Enhancer of zeste homolog 2 antibody
Enhancer of zeste, Drosophila, homolog 2 antibody
ENX 1 antibody
Enx 1h antibody
ENX-1 antibody
ENX1 antibody
Enx1h antibody
EZH 2 antibody
EZH1 antibody
EZH2 antibody
EZH2_HUMAN antibody
EZH2b antibody
Histone-lysine N-methyltransferase EZH2 antibody
KMT 6 antibody
KMT6 antibody
KMT6A antibody
Lysine N-methyltransferase 6 antibody
MGC9169 antibody
WVS antibody
WVS2 antibody

Accession NoSwiss-Prot#:Q15910

Uniprot Q15910

Gene ID 2146;

Calculated MW86 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of KMT6/EZH2 on different lysates using anti-KMT6/EZH2 antibody at 1/1,000 dilution. Positive control:
Lane 1: 293T
Lane 2: 293
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-KMT6/EZH2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-KMT6/EZH2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-KMT6/EZH2 antibody. Counter stained with hematoxylin.
ICC staining KMT6/EZH2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining KMT6/EZH2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining KMT6/EZH2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. ENX-1, a mammalian homolog of the Drosophila gene enhancer of zeste, is a PcG protein that is ubiquitously expressed during early embryogenesis and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, ENX-1 is restricted to specific sites, including spleen, testis and placenta. The gene encoding human ENX-1 transcribes a 746 amino acid polypeptide which contains a trithorax-like domain and a DNA-binding motif. ENX-1 interacts with the proto-oncogene product Vav and is thought to be involved in the proliferation of normal and malignant hematopoietic cells. By altering the regulation of target genes, ENX-1 may also contribute to certain phenotypes of Down syndrome.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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