Product Detail
Product NameSIRT5 Rabbit mAb
Clone No.JJ084-01
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesNAD dependent deacetylase sirtuin 5 antibody NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody NAD dependent protein deacylase sirtuin 5 mitochondrial antibody NAD-dependent protein deacylase sirtuin-5, mitochondrial antibody Regulatory protein SIR2 homolog 5 antibody Silent mating type information regulation 2 S.cerevisiae homolog 5 antibody Sir2 like 5 antibody SIR2-like protein 5 antibody SIR2L5 antibody SIR5_HUMAN antibody Sirt5 antibody Sirtuin 5 antibody Sirtuin type 5 antibody
Accession NoSwiss-Prot#:Q9NXA8
Uniprot
Q9NXA8
Gene ID
23408;
Calculated MW37/22 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of SIRT5 on Jurkat cells lysates using anti-SIRT5 antibody at 1/1,000 dilution.
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
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