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Location： Home > Organoid > Cardiac Troponin I Rabbit mAb

Cardiac Troponin I Rabbit mAb#49351

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Product Detail

Product NameCardiac Troponin I Rabbit mAb

Clone No.JF0550

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP

Species ReactivityHu, Ms

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Namescardiac muscle antibody
Cardiac troponin I antibody
cardiomyopathy, dilated 2A (autosomal recessive) antibody
Cardiomyopathy, familial hypertrophic, 7, included antibody
CMD1FF antibody
CMD2A antibody
CMH7 antibody
cTnI antibody
Familial hypertrophic cardiomyopathy 7 antibody
MGC116817 antibody
RCM1 antibody
Tn1 antibody
Tni antibody
TNN I3 antibody
TNNC 1 antibody
TNNC1 antibody
TNNI3 antibody
TNNI3_HUMAN antibody
Troponin I antibody
Troponin I cardiac antibody
Troponin I cardiac muscle antibody
Troponin I cardiac muscle isoform antibody
Troponin I type 3 cardiac antibody
troponin I, cardiac 3 antibody
TroponinI antibody
Ttroponin I type 3 (cardiac) antibody

Accession NoSwiss-Prot#:P19429

Uniprot P19429

Gene ID 7137;

Calculated MW24 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of Troponin I on human heart lysates using anti-Troponin I antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human heart tissue using anti-Troponin I antibody. Counter stained with hematoxylin.
ICC staining Troponin I in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Troponin I in NIH/3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer composed of two heavy chains (MHC) and four light chains (MLC); it interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin comprises at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and Troponin T (the link to the muscle thin filament). Troponin C is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Troponin C has two isoforms: fast and slow. Fast Troponin C has two calcium binding sites while slow/cardiac Troponin C has a single calcium binding site.

If you have published an article using product 49351, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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