Product Detail
Product NameMidkine Rabbit mAb
Clone No.JF096-5
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB,IHC, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAmphiregulin associated protein antibody Amphiregulin-associated protein antibody ARAP antibody FLJ27379 antibody Mdk antibody Midgestation and kidney protein antibody Midkine antibody MK 1 antibody MK antibody MK_HUMAN antibody MK1 antibody NEGF 2 antibody NEGF2 antibody Neurite growth promoting factor 2 antibody Neurite outgrowth promoting protein antibody Neurite outgrowth-promoting factor 2 antibody Neurite outgrowth-promoting protein antibody Retinoic acid inducible factor antibody
Accession NoSwiss-Prot#:P21741
Uniprot
P21741
Gene ID
4192;
Calculated MW16 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Midkine antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Midkine antibody. Counter stained with hematoxylin.
Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecules neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecules neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA).
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