Product Detail
Product NamePDI Rabbit mAb
Clone No.JF97-08
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesPancreas specific protein disulfide isomerase antibody Pancreas-specific protein disulfide isomerase antibody Pancreatic protein disulfide isomerase antibody PDA2 antibody PDI antibody PDIA2 antibody PDIA2_HUMAN antibody PDIp antibody PDIR antibody Protein disulfide isomerase A2 antibody Protein disulfide isomerase antibody Protein disulfide isomerase associated 2 antibody Protein disulfide isomerase family A member 2 antibody Protein disulfide isomerase pancreatic antibody Protein disulfide-isomerase A2 antibody Rho GDP dissociation inhibitor gamma antibody
Accession NoSwiss-Prot#:P07237
Uniprot
P07237
Gene ID
5034;
Calculated MW58 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
FC: 1:50-1:100
Western blot analysis of PDI on different lysates using anti-PDI antibody at 1/1,000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: Human liver
Flow cytometric analysis of Hela cells with PDI antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.
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