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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Thioredoxin Rabbit mAb

Thioredoxin Rabbit mAb#49416

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Product Detail

Product NameThioredoxin Rabbit mAb

Clone No.JM10-019

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP

Species ReactivityHu

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesADF antibody
ATL derived factor antibody
ATL-derived factor antibody
DKFZp686B1993 antibody
MGC61975 antibody
SASP antibody
Surface associated sulphydryl protein antibody
Surface-associated sulphydryl protein antibody
testicular tissue protein Li 199 antibody
THIO_HUMAN antibody
Thioredoxin antibody
thioredoxin delta 3 antibody
TRDX antibody
TRX 1 antibody
Trx antibody
TRX1 antibody
TXN antibody
TXN delta 3 antibody
TXN protein antibody
zgc:92903 antibody

Accession NoSwiss-Prot#:P10599

Uniprot P10599

Gene ID 7295;

Calculated MW12 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:200

Western blot analysis of TRX1 on different lysates using anti-TRX1 antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: Human lung
Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-TRX1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-TRX1 antibody. Counter stained with hematoxylin.
ICC staining TRX1 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining TRX1 in MCF-7 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining TRX1 in SKOV-3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.

If you have published an article using product 49416, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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