Product Detail
Product NameParvalbumin Rabbit mAb
Clone No.JM100-08
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesD22S749 antibody MGC116759 antibody Parvalbumin alpha antibody PRVA_HUMAN antibody PVALB antibody
Accession NoSwiss-Prot#:P20472
Uniprot
P20472
Gene ID
5816;
Calculated MW12 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Parvalbumin antibody. Counter stained with hematoxylin.
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
If you have published an article using product 49428, please notify us so that we can cite your literature.
Yes
