Product Detail
Product NameFKBP12 Rabbit mAb
Clone No.JM11-09
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names12 kDa FK506-binding protein antibody
12 kDa FKBP antibody
Calstabin 1 antibody
FK506 binding protein 1 antibody
FK506 binding protein 12 antibody
FK506 binding protein 1A (12kD) antibody
FK506 binding protein 1A 12kDa antibody
FK506 binding protein 1A antibody
FK506 binding protein T cell 12 kD antibody
FK506 binding protein, T cell, 12 kD antibody
FK506 binding protein12 antibody
FK506-binding protein 1A antibody
FKB1A_HUMAN antibody
FKBP 12 antibody
FKBP 1A antibody
FKBP-12 antibody
FKBP-1A antibody
FKBP1 antibody
FKBP12 antibody
FKBP12 Exip3 antibody
FKBP12C antibody
fkbp1a antibody
Immunophilin FKBP12 antibody
Peptidyl prolyl cis trans isomerase antibody
Peptidyl-prolyl cis-trans isomerase FKBP1A antibody
PKC12 antibody
PKCI2 antibody
PPIase antibody
PPIase FKBP1A antibody
Protein kinase C inhibitor 2 antibody
Rotamase antibody
Accession NoSwiss-Prot#:P62942
Uniprot
P62942
Gene ID
2280;
Calculated MW12 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
ICC: 1:100-1:500
Western blot analysis of FKBP12 on different cells lysates using anti-FKBP12 antibody at 1/500 dilution. Positive control:
Line 1: SH-SY5Y
Line 2:V937
ICC staining FKBP12 in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining FKBP12 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining FKBP12 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBP-type PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing.
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