Product Detail
Product NameADAM10 Rabbit mAb
Clone No.JM32-11
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesA disintegrin and metalloprotease domain 10 antibody
A disintegrin and metalloproteinase domain 10 antibody
AD 10 antibody
AD10 antibody
AD18 antibody
ADA10_HUMAN antibody
ADAM 10 antibody
ADAM metallopeptidase domain 10 antibody
ADAM10 antibody
CD 156c antibody
CD156c antibody
CD156c antigen antibody
CDw156 antibody
disintegrin and metalloproteinase domain containing protein 10 antibody
Disintegrin and metalloproteinase domain-containing protein 10 antibody
HsT 18717 antibody
HsT18717 antibody
Kuz antibody
Kuzbanian antibody
Kuzbanian protein homolog antibody
Kuzbanian, Drosophila, homolog of antibody
MADM antibody
Mammalian disintegrin metalloprotease antibody
Mammalian disintegrin-metalloprotease antibody
RAK antibody
Accession NoSwiss-Prot#:O14672
Uniprot
O14672
Gene ID
102;
Calculated MW84 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IP: 1:10-1:50
Western blot analysis of ADAM10 on different cells lysates using anti-ADAM10 antibody at 1/500 dilution. Positive control��
Line 1: Jurkat
Line 2: Hela
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.
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