Product Detail
Product NameNeuroD1 Rabbit mAb
Clone No.JM11-10
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Namesatonal antibody
basic helix loop helix transcription factor antibody
BETA 2 antibody
Beta cell E box transactivator 2 antibody
BETA2 antibody
BHF 1 antibody
BHF1 antibody
bHLHa3 antibody
class A basic helix loop helix protein 3 antibody
Class A basic helix-loop-helix protein 3 antibody
MODY 6 antibody
MODY6 antibody
NDF1_HUMAN antibody
NeuroD antibody
NeuroD1 antibody
Neurogenic differentiation 1 antibody
Neurogenic differentiation factor 1 antibody
neurogenic helix loop helix protein NEUROD antibody
Neuronal differentiation 1 antibody
Accession NoSwiss-Prot#:Q13562
Uniprot
Q13562
Gene ID
4760;
Calculated MW45 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IP: 1:10-1:50
Western blot analysis of NeuroD1 on different cells lysates using anti-NeuroD1 antibody at 1/500 dilution. Positive control:
Line 1: human brain
Line 2:SH-SY5Y
The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. The HLH domain is required for dimerization, while the basic region makes specific contacts with DNA. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains. These proteins heterodimerize with members of the E protein family and initiate myogenesis. Neuro D has been identified as a bHLH transcription factor functioning in neurogenic differentiation. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.
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