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Rac1-2-3 Rabbit mAb#49493

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Product NameRac1-2-3 Rabbit mAb

Clone No.JM11-29

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesCell migration inducing gene 5 protein antibody
EN 7 antibody
OTTMUSP00000004488 antibody
p21 Rac3 antibody
p21-Rac3 antibody
Rac1B antibody
RAC3 antibody
RAC3_HUMAN antibody
RAS related C3 botulinum substrate 3 antibody
Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) antibody
Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) antibody
Ras-related C3 botulinum toxin substrate 3 antibody
Rho family small GTP binding protein Rac3 antibody
RP23-84C12.18 antibody
EN-7 antibody
EN7 antibody
GX antibody
HSPC 022 antibody
HSPC022 antibody
p21 Rac 2 antibody
p21 Rac2 antibody
p21-Rac2 antibody
p21Rac2 antibody
RAC 2 antibody
Rac2 antibody
RAC2_HUMAN antibody
Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2 antibody
Ras related C3 botulinum toxin substrate 2 antibody
Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2) antibody
Ras related C3 botulinum toxin substrate 3 antibody
Ras-related C3 botulinum toxin substrate 2 antibody
Rho family small GTP binding protein Rac 2 antibody
Rho family small GTP binding protein Rac2 antibody
Small G protein antibody
Cell migration-inducing gene 5 protein antibody
MGC111543 antibody
MIG5 antibody
Migration inducing gene 5 antibody
Migration inducing protein 5 antibody
p21 Rac1 antibody
p21-Rac1 antibody
Rac 1 antibody
RAC1 antibody
RAC1_HUMAN antibody
Ras like protein TC25 antibody
Ras related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody
Ras-like protein TC25 antibody
Ras-related C3 botulinum toxin substrate 1 antibody
Rho family small GTP binding protein Rac1 antibody
TC 25 antibody
TC25 antibody

Accession NoSwiss-Prot#:P63000

Uniprot P63000

Gene ID 5879;

Calculated MW21/24 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of RAC1/2/3 on MCF-7 cells lysates using anti-RAC1/2/3 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RAC1/2/3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-RAC1/2/3 antibody. Counter stained with hematoxylin.
ICC staining RAC1/2/3 in 293T cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RAC1/2/3 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RAC1/2/3 in NIH-3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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