Product Detail
Product NameMyoD1 Rabbit mAb
Clone No.JM10-72
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesbHLHc1 antibody
Class C basic helix-loop-helix protein 1 antibody
MYF 3 antibody
Myf-3 antibody
MYF3 antibody
Myoblast determination protein 1 antibody
Myod 1 antibody
MYOD antibody
MYOD1 antibody
MYOD1_HUMAN antibody
Myogenic differentiation 1 antibody
Myogenic factor 3 antibody
Myogenic factor MYF 3 antibody
Myogenin D1 antibody
PUM antibody
Accession NoSwiss-Prot#:P15172
Uniprot
P15172
Gene ID
4654;
Calculated MW45 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
IP: 1:10-1:50
FC: 1:50-1:100
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either MyoD or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. MyoD transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. MyoD-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.
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