Product Detail
Product NameAxin2 Rabbit mAb
Clone No.JM11-30
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAxil antibody
Axin like protein antibody
Axin-2 antibody
Axin-like protein antibody
Axin2 antibody
AXIN2_HUMAN antibody
Axis inhibition protein 2 antibody
Conductin antibody
DKFZp781B0869 antibody
MGC10366 antibody
MGC126582 antibody
Accession NoSwiss-Prot#:Q9Y2T1
Uniprot
Q9Y2T1
Gene ID
8313;
Calculated MW94 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:10-1:50
ICC: 1:50-1:200
b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.
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