Product Detail
Product NameCalcineurin A Rabbit mAb
Clone No.JA64-11
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAlpha isoform formerly PPP2B antibody
Calcineurin A alpha antibody
Calcineurin A1 antibody
CalcineurinA antibody
Calmodulin dependent calcineurin A subunit alpha isoform antibody
Calmodulin-dependent calcineurin A subunit alpha isoform antibody
CALN antibody
CALNA 1 antibody
CALNA antibody
CALNA1 antibody
CAM PRP catalytic subunit antibody
CAM-PRP catalytic subunit antibody
CCN 1 antibody
CCN1 antibody
CNA 1 antibody
CNA alpha antibody
CNA antibody
CNA1 antibody
PP2BA_HUMAN antibody
PPP2B antibody
Ppp3ca antibody
Protein phosphatase 2B catalytic subunit antibody
Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody
Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody
Protein phosphatase 3 catalytic subunit alpha isozyme antibody
Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody
Accession NoSwiss-Prot#:Q08209
Uniprot
Q08209
Gene ID
5530;
Calculated MW59 kD
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
FC: 1:50-1:100
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-Aα, PP2B-Aβ and PP2B-Aγ. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2.
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