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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Vitamin D Receptor Rabbit mAb

Vitamin D Receptor Rabbit mAb#49521

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Product Detail

Product NameVitamin D Receptor Rabbit mAb

Clone No.JA11-16

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names1 25 dihydroxyvitamin D3 receptor antibody
1 antibody
1,25 dihydroxyvitamin D3 receptor antibody
1,25-@dihydroxyvitamin D3 receptor antibody
25-dihydroxyvitamin D3 receptor antibody
Member 1 antibody
NR1I1 antibody
Nuclear receptor subfamily 1 group I member 1 antibody
PPP1R163 antibody
Protein phosphatase 1, regulatory subunit 163 antibody
VDR antibody
VDR_HUMAN antibody
Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
Vitamin D hormone receptor antibody
Vitamin D nuclear receptor variant 1 antibody
Vitamin D receptor antibody
Vitamin D3 receptor antibody

Accession NoSwiss-Prot#:P11473

Uniprot P11473

Gene ID 7421;

Calculated MW48 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200


FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti- Vitamin D Receptor antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti- Vitamin D Receptor antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti- Vitamin D Receptor antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with Vitamin D Receptor antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
he active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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