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Location： Home > Recombinant Rabbit Monoclonal Antibodies > MHC Class II Rabbit mAb

MHC Class II Rabbit mAb#49525

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Product Detail

Product NameMHC Class II Rabbit mAb

Clone No.JA10-94

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IP, ICC/IF, IHC

Species ReactivityHu

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesD6S221E antibody
DMA antibody
DMB antibody
DP beta 1 antibody
DP beta 1 chain antibody
DP(W4) beta chain antibody
DPB 1 antibody
DPB1 antibody
DPB1_HUMAN antibody
DRB antibody
H2Ea antibody
HLA class II histocompatibility antigen antibody
HLA class II histocompatibility antigen DM beta chain antibody
HLA class II histocompatibility antigen, DP beta 1 chain antibody
HLA class II histocompatibility antigen, DP(W4) beta chain antibody
HLA DMB antibody
HLA DP1A antibody
HLA DPB1 antibody
HLA SB alpha chain antibody
HLA-A antibody
HLA-A histocompatibility type antibody
HLA-DP antibody
HLA-DP histocompatibility type, beta-1 subunit antibody
HLA-DP1B antibody
HLA-DPB antibody
HLA-DPB1 antibody
HLADM antibody
HLADP1B antibody
HLASB antibody
HLASB histocompatibility type antibody
Human MHC class II HLA SB alpha antibody
LA class II histocompatibility antigen DP alpha 1 chain antibody
Major histocompatibility complex class II antibody
Major histocompatibility complex class II DP alpha 1 antibody
Major histocompatibility complex class II DP beta 1 antibody
Major histocompatibility complex, class I, A antibody
MHC class II antigen DMB antibody
MHC class II antigen DPB1 antibody
MHC class II DP3 alpha antibody
MHC class II DPA1 antibody
MHC class II HLA-DP-beta-1 antibody
MHC DPB1 antibody
MHC HLA DPB1 antibody
PLT1 antibody
Primed lymphocyte test 1 antibody
RING6 antibody
RING7 antibody

Accession NoSwiss-Prot#:P04440

Uniprot P04440

Gene ID 3115;

Calculated MW29 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:100
IP: 1:10-1:50
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.
Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

If you have published an article using product 49525, please notify us so that we can cite your literature.

et al,Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension. In J Am Heart Assoc on 2021 Jan 5 by Xuejing Sun, Mengli Zhou, et al..PMID:33372534 , (2021),
PMID: 33372534

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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