Product Detail
Product NameLin28 Rabbit mAb
Clone No.JA10-63
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAL024421 antibody
CSDD1 antibody
CSDD2 antibody
FLJ12457 antibody
Lin 28 antibody
Lin 28 homolog (C. elegans) antibody
Lin 28 homolog A (C. elegans) antibody
Lin 28 homolog A antibody
Lin 28 homolog antibody
Lin-28A antibody
Lin28 antibody
Lin28, C. elegans, homolog of, A antibody
LIN28A antibody
LN28A_HUMAN antibody
Protein lin-28 homolog A antibody
Protein lin-28 homolog B antibody
RNA binding protein lin 28 antibody
Tex17 antibody
ZCCHC1 antibody
Zinc finger CCHC domain containing 1 antibody
Zinc finger CCHC domain containing protein 1 antibody
Zinc finger CCHC domain-containing protein 1 antibody
Accession NoSwiss-Prot#:Q9H9Z2
Uniprot
Q9H9Z2
Gene ID
79727;
Calculated MW23 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IP: 1:10-1:50
FC: 1:50-1:100
Western blot analysis of Lin-28 on NCCIT cells lysates using anti-Lin-28 antibody at 1/500 dilution.
Flow cytometric analysis of Hela cells with Lin-28 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein sysnthesis efficiency and binds to the growth and differentiation factor IGF-II.
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