Product Detail
Product NameGDNF Rabbit mAb
Clone No.JA93-10
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAstrocyte derived trophic factor antibody
Astrocyte derived trophic factor 1 antibody
Astrocyte-derived trophic factor antibody
ATF 1 antibody
ATF 2 antibody
Atf antibody
ATF1 antibody
ATF2 antibody
gdnf antibody
GDNF_HUMAN antibody
Glial cell derived neurotrophic factor antibody
Glial Cell Line Derived Neurotrophic Factor antibody
Glial cell line-derived neurotrophic factor antibody
Glial derived neurotrophic factor antibody
HFB1 GDNF antibody
hGDNF antibody
HSCR3 antibody
Accession NoSwiss-Prot#:P39905
Uniprot
P39905
Gene ID
2668;
Calculated MW24 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:200
Western blot analysis of GDNF on HepG2 cell using anti-GDNF antibody at 1/1,000 dilution.
Flow cytometric analysis of SH-SY5Y cells with GDNF antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer and is a distantly related member of the TGFβ superfamily of growth regulatory ligands. GDNF contains the seven conserved cysteine residues in the same relative spacing characteristic of all members of the TGFβ superfamily. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been suggested that GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.
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