Product Detail
Product NameMRP1 Rabbit mAb
Clone No.JA93-03
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesABC 29 antibody
ABC29 antibody
ABCC 1 antibody
ABCC antibody
Abcc1 antibody
ATP binding cassette sub family C (CFTR/MRP) member 1 antibody
ATP binding cassette sub-family C member 1 antibody
ATP binding cassette subfamily C member 1 antibody
ATP binding cassette transporter variant ABCC1delta ex13 antibody
ATP binding cassette transporter variant ABCC1delta ex13&14 antibody
ATP binding cassette transporter variant ABCC1delta ex25 antibody
ATP binding cassette transporter variant ABCC1delta ex25&26 antibody
ATP binding cassette, sub-family C (CFTR/MRP), member 1 antibody
ATP-binding cassette sub-family C member 1 antibody
DKFZp686N04233 antibody
DKFZp781G125 antibody
GS X antibody
GSX antibody
Leukotriene C(4) transporter antibody
LTC4 transporter antibody
MRP 1 antibody
MRP antibody
MRP1 antibody
MRP1_HUMAN antibody
Multidrug resistance associated protein 1 antibody
Multidrug resistance protein antibody
Multidrug resistance-associated protein 1 antibody
Multiple drug resistance associated protein antibody
Multiple drug resistance protein 1 antibody
Accession NoSwiss-Prot#:P33527
Uniprot
P33527
Gene ID
4363;
Calculated MW171 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MRP1 antibody. Counter stained with
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MRP1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with MRP1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an Mdr-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.
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