Product Detail
Product NameAggrecan Rabbit mAb
Clone No.JA40-23
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsIHC
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesACAN antibody
AGC 1 antibody
AGC1 antibody
AGCAN antibody
Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody
A0122) antibody
Aggrecan 1 antibody
Aggrecan core protein antibody
Aggrecan proteoglycan antibody
Aggrecan structural proteoglycan of cartilage antibody
Aggrecan1 antibody
ATEGQV antibody
Cartilage specific proteoglycan core protein antibody
Chondroitin sulfate proteoglycan 1 antibody
Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody
A0122 antibody
Chondroitin sulfate proteoglycan core protein 1 antibody
CSPG 1 antibody
CSPG1 antibody
CSPGCP antibody
JSCATE antibody
Large aggregating proteoglycan antibody
mcspg antibody
mgsk16 antibody
MSK 16 antibody
MSK16 antibody
SEDK antibody
Accession NoSwiss-Prot#:P16112
Uniprot
P16112
Gene ID
176;
Calculated MW250/246/239 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded rat cartilage tissue using anti-Aggrecan antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Aggrecan antibody. Counter stained with hematoxylin.
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.
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