Product Detail
Product NamePeriostin Rabbit mAb
Clone No.JA63-40
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesFasciclin-I like antibody
MGC119510 antibody
MGC119511 antibody
OSF 2 antibody
OSF-2 antibody
OSF2 antibody
Osteoblast specific factor 2 (fasciclin I like) antibody
Osteoblast specific factor 2 antibody
Osteoblast specific factor antibody
Osteoblast-specific factor 2 antibody
PDLPOSTN antibody
Periodontal ligament specific periostin antibody
Periostin antibody
Periostin isoform thy2 antibody
Periostin isoform thy4 antibody
Periostin isoform thy6 antibody
Periostin isoform thy8 antibody
Periostin osteoblast specific factor antibody
PN antibody
POSTN antibody
POSTN_HUMAN antibody
RP11 412K4.1 antibody
Accession NoSwiss-Prot#:Q15063
Uniprot
Q15063
Gene ID
10631;
Calculated MW89 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
FC: 1:50-1:100
Western blot analysis of Periostin on human placenta tissue lysate using anti-Periostin antibody at 1/1,000 dilution.
Flow cytometric analysis of 293T cells with Periostin antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta and alpha(V)beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1(TGF β 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
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