Product Detail
Product NamePDCD4 Rabbit mAb
Clone No.JA80-83
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, IHC, FC
Species ReactivityHu, Ms
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesDeath up-regulated gene protein antibody
Dug antibody
H731 antibody
Ma3 antibody
MGC33046 antibody
MGC33047 antibody
Neoplastic transformation inhibitor antibody
Neoplastic transformation inhibitor protein antibody
Nuclear antigen H731 antibody
Nuclear antigen H731 like antibody
Nuclear antigen H731 like protein antibody
Nuclear antigen H731-like antibody
PDCD 4 antibody
Pdcd4 antibody
PDCD4_HUMAN antibody
Programmed cell death 4 antibody
programmed cell death 4 (neoplastic transformation inhibitor) antibody
Programmed cell death protein 4 antibody
Protein 197/15a antibody
Protein MA-3 antibody
Tis antibody
Topoisomerase-inhibitor suppressed protein antibody
Accession NoSwiss-Prot#:Q53EL6
Uniprot
Q53EL6
Gene ID
27250;
Calculated MW52 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500
IHC: 1:50-1:200
ICC: 1:20-1:50
FC: 1:50-1:100
The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun.
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