Product Detail
Product NameCXCR3 Rabbit mAb
Clone No.JA61-33
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesC-X-C chemokine receptor type 3 antibody
CD 183 antibody
CD182 antibody
CD183 antibody
Chemokine (C X C motif) receptor 3 antibody
Chemokine (C X C) receptor 3 antibody
Chemokine CXC Motif Receptor 3 antibody
CKR L2 antibody
CKR-L2 antibody
CKRL2 antibody
CMKAR3 antibody
CXC-R3 antibody
CXCR-3 antibody
CXCR3 antibody
CXCR3_HUMAN antibody
G Protein Coupled Receptor 9 antibody
G protein-coupled receptor 9 antibody
GPR9 antibody
Interferon-inducible protein 10 receptor antibody
IP-10 receptor antibody
IP10 antibody
IP10 R antibody
IP10 receptor antibody
IP10-R antibody
IP10R antibody
Mig R antibody
Mig receptor antibody
Mig-R antibody
MIGR antibody
Accession NoSwiss-Prot#:P49682
Uniprot
P49682
Gene ID
2833;
Calculated MW41 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
ICC: 1:50-1:200
Western blot analysis of CXCR3 on Hela cell using anti-CXCR3 antibody at 1/1,000 dilution.
ICC staining CXCR3 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining CXCR3 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining CXCR3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The C-X-C or α chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has since been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). CXCR-3, also known as IP-10/MIG receptor, mediates Ca2+ mobilization and chemotaxis in response to the C-X-C chemokines IP-10 and MIG. CXCR-3 is highly expressed in IL-2-activated T lymphocytes, but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes.
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