Product Detail
Product NameReelin Rabbit mAb
Clone No.JA63-13
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesLIS2 antibody
PRO1598 antibody
Reeler antibody
Reelin antibody
RELN antibody
RELN_HUMAN antibody
RL antibody
Accession NoSwiss-Prot#:P78509
Uniprot
P78509
Gene ID
5649;
Calculated MW388 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in "reeler" mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF.
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