Product Detail
Product NameC4 Rabbit mAb
Clone No.JM88-13
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesAcidic C4 antibody
Acidic complement C4 antibody
Basic C4 antibody
Basic complement C4 antibody
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 antibody
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody
C4, Chido form antibody
C4, Rodgers from antibody
C4A anaphylatoxin antibody
C4A antibody
C4A2 antibody
C4A3 antibody
C4A4 antibody
C4A6 antibody
C4AD antibody
C4B antibody
C4B_2 antibody
C4B1 antibody
C4B12 antibody
C4B2 antibody
C4B3 antibody
C4BD antibody
C4F antibody
C4S antibody
CH antibody
Chido form of C4 antibody
CO4 antibody
CO4A_HUMAN antibody
Complement C4 gamma chain antibody
complement C4-A antibody
complement C4-B antibody
complement C4-B-like antibody
complement C4B1a antibody
Complement component 4A (Rodgers blood group) antibody
Complement component 4A antibody
complement component 4B (Chido blood group), copy 2 antibody
Complement component 4B (Childo blood group) antibody
Complement component 4B antibody
Complement component 4F antibody
Complement component 4S antibody
CPAMD2 antibody
CPAMD3 antibody
RG antibody
Rodgers form of C4 antibody
Accession NoSwiss-Prot#:P0C0L4
Uniprot
P0C0L4
Gene ID
720;721;
Calculated MW193 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:200-1:500
IHC: 1:50-1:200
ICC: 1:50-1:200
The complement component proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage. These proteins belong to the α2-macroglobulin family, but retain distinctive features including an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B, mapping to chromosome 6p21.32. C4A expresses the Rodgers (Rg) blood group Ag, while C4B expresses the Chido (Ch) blood group Ag. C4 is expressed as a precursor that is cleaved into α, β and γ chains, all of which are non-identical cleavage products. The α chain of C4 may be cleaved to produce an acidic isotype, C4a, which reacts with amino groups, and a basic isotype, C4b, which reacts with hydroxyl groups. Deficiency in the C4 gene is associated with autoimmune or immune complex disorders, such as systemic lupus erythematosus.
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