Product Detail
Product NameTAK1 Rabbit mAb
Clone No.JM73-19
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC, FC
Species ReactivityHu, Ms
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesM3K7_HUMAN antibody
MAP3K 7 antibody
Map3k7 antibody
MEKK7 antibody
Mitogen activated protein kinase kinase kinase 7 antibody
Mitogen-activated protein kinase kinase kinase 7 antibody
TAK1 antibody
TGF beta activated kinase 1 antibody
TGF-beta-activated kinase 1 antibody
TGF1a antibody
Transforming growth factor beta activated kinase 1 antibody
Transforming growth factor-beta-activated kinase 1 antibody
Accession NoSwiss-Prot#:O43318
Uniprot
O43318
Gene ID
6885;
Calculated MW67 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500
IHC: 1:50-1:100
ICC: 1:50-1:100
FC: 1:50-1:100
Several serine / threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK / MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine / threonine residues and Which is expressed expression in many human types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation is poorly understood. Two proteins put put involved in this process are Ksr-1 and Taks. Ksr-1 (kinase sup-pressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether or not in a parallel pathway is not yet known. Tak1 (TGFβ-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFβ stimulation.
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