Product Detail
Product NameCD1a Rabbit mAb
Clone No.JM21-33
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCD 1a antibody
CD1 antibody
CD1a antibody
CD1A Antigen antibody
CD1A antigen, a polypeptide antibody
CD1a molecule antibody
CD1A_HUMAN antibody
cluster of differentiation 1 A antibody
cortical thymocyte antigen CD1A antibody
differentiation antigen CD1 alpha 3 antibody
epidermal dendritic cell marker CD1a antibody
FCB 6 antibody
FCB6 antibody
HTA 1 antibody
HTA1 antibody
hTa1 thymocyte antigen antibody
OTTHUMP00000018907 antibody
R 4 antibody
R4 antibody
T 6 antibody
T-cell surface antigen T6/Leu-6 antibody
T-cell surface glycoprotein CD1a antibody
T6 antibody
Accession NoSwiss-Prot#:P06126
Uniprot
P06126
Gene ID
909;
Calculated MW37 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD1a antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-CD1a antibody. Counter stained with hematoxylin.
The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.
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