Product Detail
Product NameDynamin 2 Rabbit mAb
Clone No.JM61-38
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesCMT2M antibody
CMTDI1 antibody
CMTDIB antibody
DI CMTB antibody
Dnm2 antibody
DYN II antibody
DYN2 antibody
DYN2_HUMAN antibody
Dynamin II antibody
Dynamin-2 antibody
Dynamin2 antibody
DynaminII antibody
DYNII antibody
Accession NoSwiss-Prot#:P50570
Uniprot
P50570
Gene ID
1785;
Calculated MW98 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:100-1:500
FC: 1:50-1:100
Members of the dynamin family, including Dynamin I and Dynamin II, are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.
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