Product Detail
Product NameACE Rabbit mAb
Clone No.JM59-32
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, FC
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesACE 1 antibody
ACE antibody
ACE T antibody
ACE_HUMAN antibody
ACE1 antibody
Angiotensin converting enzyme somatic isoform antibody
Angiotensin converting enzyme testis specific isoform antibody
Angiotensin I converting enzyme 1 antibody
Angiotensin I converting enzyme antibody
Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody
angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript antibody
Angiotensin-converting enzyme antibody
Carboxycathepsin antibody
CD 143 antibody
CD143 antibody
CD143 antigen antibody
DCP 1 antibody
DCP antibody
DCP1 antibody
Dipeptidyl carboxypeptidase 1 antibody
Dipeptidyl carboxypeptidase I antibody
Kininase II antibody
MGC26566 antibody
MVCD3 antibody
Peptidase P antibody
Peptidyl dipeptidase A antibody
soluble form antibody
Testicular ECA antibody
Accession NoSwiss-Prot#:P12821
Uniprot
P12821
Gene ID
1636;
Calculated MW160 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:100-1:500
FC: 1:50-1:100
Western blot analysis of ACE on human lung (1) and mouse kidney (2) cell lysate using anti-ACE antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACE antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-ACE antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-ACE antibody. Counter stained with hematoxylin.
Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE, ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac, renal and testicular cells.
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