Product Detail
Product NameIKB epsilon Rabbit mAb
Clone No.JM62-63
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesI kappa B epsilon antibody
I-kappa-B-epsilon antibody
IkappaBepsilon antibody
IkB E antibody
IkB-E antibody
IkB-epsilon antibody
IKBE antibody
IKBE_HUMAN antibody
MGC72568 antibody
NF kappa B inhibitor epsilon antibody
NF kappa BIE antibody
NF-kappa-B inhibitor epsilon antibody
NF-kappa-BIE antibody
NFkappa BIE antibody
NFkappaB inhibitor epsilon antibody
NFKBIE antibody
Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody
OTTHUMP00000016522 antibody
Slc35b2 antibody
solute carrier family 35, member B2 antibody
Accession NoSwiss-Prot#:O00221
Uniprot
O00221
Gene ID
4794;
Calculated MW45 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
On the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, which is identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and is expressed predominantly in lymphoid cells. An additional IκB family member, IκB-ε, has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.
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