Product Detail
Product Namec-Rel Rabbit mAb
Clone No.JM72-93
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IHC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesAvian reticuloendotheliosis antibody
C REL antibody
C Rel protein antibody
c Rel proto oncogene protein antibody
Oncogene REL antibody
Oncogene REL avian reticuloendotheliosis antibody
Proto-oncogene c-Rel antibody
REL antibody
REL_HUMAN antibody
v rel avian reticuloendotheliosis viral oncogene homolog antibody
v rel reticuloendotheliosis viral oncogene homolog antibody
V rel reticuloendotheliosis viral oncogene homolog (avian) antibody
Accession NoSwiss-Prot#:Q04864
Uniprot
Q04864
Gene ID
5966;
Calculated MW68 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-c-Rel antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-c-Rel antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-c-Rel antibody. Counter stained with hematoxylin.
c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the κB site binding transcription factor NFκB, which plays a crucial role in the expression of immunoglobulin κ light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NFκB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormone-responsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.
If you have published an article using product 49632, please notify us so that we can cite your literature.
Yes
