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Location： Home > Recombinant Rabbit Monoclonal Antibodies > PI 3 Kinase p110 delta Rabbit mAb

PI 3 Kinase p110 delta Rabbit mAb#49634

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Product NamePI 3 Kinase p110 delta Rabbit mAb

Clone No.JM83-24

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC

Species ReactivityHu, Ms, Rt

Immunogen DescRecombinant protein

ConjugateUnconjugated

Other Names5-bisphosphate 3-kinase 110 kDa catalytic subunit delta antibody
5-bisphosphate 3-kinase catalytic subunit delta isoform antibody
APDS antibody
GRB1 antibody
IMD14 antibody
p110d antibody
p110delta antibody
p110dp85a antibody
p85-ALPHA antibody
Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody
Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform antibody
Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta antibody
Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta antibody
Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform antibody
Phosphatidylinositol-4 antibody
Phosphoinositide 3 kinase B antibody
Phosphoinositide 3 kinase C antibody
Phosphoinositide 3 kinase catalytic delta polypeptide antibody
Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta antibody
PI3 kinase p110 subunit delta antibody
PI3-kinase subunit delta antibody
PI3K antibody
PI3K-delta antibody
PI3Kdelta antibody
Pik3cd antibody
PIK3R1 antibody
PK3CD antibody
PK3CD_HUMAN antibody
PtdIns 3 kinase p110 antibody
PtdIns 3 kinase subunit p110 delta antibody
PtdIns-3-kinase subunit delta antibody
PtdIns-3-kinase subunit p110-delta antibody

Accession NoSwiss-Prot#:O00329

Uniprot O00329

Gene ID 5293;

Calculated MW110 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500
IHC: 1:50-1:200


Western blot analysis of PI 3 Kinase p110 delta on mouse spleen tissue lysate using anti-PI 3 Kinase p110 delta antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PI 3 Kinase p110 delta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-PI 3 Kinase p110 delta antibody. Counter stained with hematoxylin.
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110γ does not interact with the p85 subunits and has been shown to be activated by α and βγ heterotrimeric G proteins. Two p110δ isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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